The common factor that distinguishes patients in both antiphospholipid syndrome (APS) and Type 2 diabetes is that both patients have reductions in the bioavailability of nitric oxide. That is to say both have an impaired absorption of nitric oxide that would otherwise be naturally produced mainly within the endothelial cells of the vasculature. It has been shown that the role of l-arginine and l-citrulline supplementation in both of these diseases can help as indicated at the medical journal Science Direct here.
APS is a disorder of the immune system that increases the risk of developing conditions such as deep vein thrombosis. Studies have shown that this increased risk of a blood clot is because of the ‘interactions between circulating aPL and cell surface molecules of target cells, primarily endothelial cells and platelets, underlie the vascular disease phenotypes of APS’ according to research by C Mineo. It goes onto discuss the beneficial role that l-arginine can play.
Type 2 Diabetes
Similarly a study published by the International Journal of Endocrinology carried out on rats showed that ‘type II diabetes mellitus (T2DM) decreases both the production and bioavailability of nitric oxide (NO)’. It goes onto say that the rats which were treated with l-arginine had a delay in ‘the onset of insulin resistance and renal dysfunction’.
The benefits in increasing nitric oxide production by l-arginine supplementation is seen to be beneficial with these two diseases. Nitric oxide suppression in other diseases may also be a factor; these are only two cited here in which l-arginine is proven to help. However, as with all natural supplements advice should always be sought from your doctor first*.
L-arginine plus is now available to purchase in the UK found here